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Last updated: 2017/6/25
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Scientific Image Contest
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MSH2 & MLH1 Protein Protein Interaction Antibody Pair

  • Catalog # : DI0328
  • Visit Frequency :
  • Countries :
  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0328
    Representative image of Proximity Ligation Assay of protein-protein interactions between MSH2 and MLH1. HeLa cells were stained with anti-MSH2 rabbit purified polyclonal antibody 1:1200 and anti-MLH1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. MSH2 rabbit purified polyclonal antibody (20 ug)
    2. MLH1 mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 4436
  • Gene Name:
  • MSH2
  • Gene Alias:
  • COCA1,FCC1,HNPCC,HNPCC1,LCFS2
  • Gene Description:
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
  • Gene Summary:
  • MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq
  • Other Designations:
  • mutS homolog 2
  • Gene Information
  • Entrez GeneID:
  • 4292
  • Gene Name:
  • MLH1
  • Gene Alias:
  • COCA2,FCC2,HNPCC,HNPCC2,MGC5172,hMLH1
  • Gene Description:
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  • Gene Summary:
  • This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq
  • Other Designations:
  • DNA mismatch repair protein Mlh1,MutL protein homolog 1
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