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Last updated: 2017/7/23
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PARK2 & GRIN2B Protein Protein Interaction Antibody Pair

  • Catalog # : DI0233
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0233
    Representative image of Proximity Ligation Assay of protein-protein interactions between PARK2 and GRIN2B. HeLa cells were stained with anti-PARK2 rabbit purified polyclonal antibody 1:1200 and anti-GRIN2B mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. PARK2 rabbit purified polyclonal antibody (20 ug)
    2. GRIN2B mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 5071
  • Gene Name:
  • PARK2
  • Gene Alias:
  • AR-JP,LPRS2,PDJ,PRKN
  • Gene Description:
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • Gene Summary:
  • The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq
  • Other Designations:
  • E3 ubiquitin ligase,OTTHUMP00000017565,OTTHUMP00000017566,OTTHUMP00000017567,parkin,parkin 2
  • Gene Information
  • Entrez GeneID:
  • 2904
  • Gene Name:
  • GRIN2B
  • Gene Alias:
  • MGC142178,MGC142180,NMDAR2B,NR2B,hNR3
  • Gene Description:
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B
  • Gene Summary:
  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq
  • Other Designations:
  • N-methyl-D-aspartate receptor subunit 2B,glutamate receptor subunit epsilon-2
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