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In situ Proximity Ligation Assay (Cell)

Representative image of Proximity Ligation Assay of protein-protein interactions between SMARCB1 and BAZ1B. Huh7 cells were stained with anti-SMARCB1 rabbit purified polyclonal antibody 1:1200 and anti-BAZ1B mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

6598

Gene Name

SMARCB1

Gene Alias

BAF47, INI1, RDT, SNF5, SNF5L1, Sfh1p, Snr1, hSNFS

Gene Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Omim ID

601607

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

integrase interactor 1|malignant rhabdoid tumor suppressor|sucrose nonfermenting, yeast, homolog-like 1

Entrez GeneID

9031

Gene Name

BAZ1B

Gene Alias

WBSCR10, WBSCR9, WSTF

Gene Description

bromodomain adjacent to zinc finger domain, 1B

Omim ID

605681

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq

Other Designations

Williams-Beuren syndrome chromosome region 10|Williams-Beuren syndrome chromosome region 9|transcription factor WSTF