FGA & F2 Protein Protein Interaction Antibody Pair
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Specification
Product Description
This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the FGA protein, and the other against the F2 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.
Reactivity
Human
Quality Control Testing
Protein protein interaction immunofluorescence result.
Representative image of Proximity Ligation Assay of protein-protein interactions between FGA and F2. HeLa cells were stained with anti-FGA rabbit purified polyclonal antibody 1:1200 and anti-F2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
Supplied Product
Antibody pair set content:
1. FGA rabbit purified polyclonal antibody (100 ug)
2. F2 mouse monoclonal antibody (40 ug)
*Reagents are sufficient for at least 30-50 assays using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
In situ Proximity Ligation Assay (Cell)
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Gene Info — F2
Entrez GeneID
2147Gene Name
F2
Gene Alias
PT
Gene Description
coagulation factor II (thrombin)
Omim ID
176930Gene Ontology
HyperlinkGene Summary
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq
Other Designations
coagulation factor II|prothrombin B-chain|serine protease
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Gene Info — FGA
Entrez GeneID
2243Gene Name
FGA
Gene Alias
Fib2, MGC119422, MGC119423, MGC119425
Gene Description
fibrinogen alpha chain
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq
Other Designations
fibrinogen, A alpha polypeptide|fibrinogen, alpha chain, isoform alpha preproprotein|fibrinogen, alpha polypeptide
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Interactome
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Disease
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