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MAP3K7 & CHUK Protein Protein Interaction Antibody Pair

  • Catalog # : DI0099
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  • Specification
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Protein protein interaction immunofluorescence result.

    QC Testing of DI0099
    Representative image of Proximity Ligation Assay of protein-protein interactions between MAP3K7 and CHUK. HeLa cells were stained with anti-MAP3K7 rabbit purified polyclonal antibody 1:1200 and anti-CHUK mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.
  • Supplied Product:
  • Antibody pair set content:
    1. MAP3K7 rabbit purified polyclonal antibody (20 ug)
    2. CHUK mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Publication Reference
  • Applications
  • In situ Proximity Ligation Assay (Cell)
  • Application Image
  • In situ Proximity Ligation Assay (Cell)
  • Gene Information
  • Entrez GeneID:
  • 6885
  • Gene Name:
  • MAP3K7
  • Gene Alias:
  • TAK1,TGF1a
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 7
  • Gene Summary:
  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000016870,OTTHUMP00000016871,OTTHUMP00000016872,OTTHUMP00000016873,TGF-beta activated kinase 1,transforming growth factor-beta-activated kinase 1
  • Gene Information
  • Entrez GeneID:
  • 1147
  • Gene Name:
  • CHUK
  • Gene Alias:
  • IKBKA,IKK-alpha,IKK1,IKKA,NFKBIKA,TCF16
  • Gene Description:
  • conserved helix-loop-helix ubiquitous kinase
  • Gene Summary:
  • This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq
  • Other Designations:
  • I-kappa-B kinase 1,I-kappa-B kinase-alpha,IKK-a kinase,IkB kinase alpha subunit,Nuclear factor NFkappaB inhibitor kinase alpha,OTTHUMP00000020273,conserved helix-loop ubiquitous kinase
  • Interactome 1
  • Interactome
  • Interactome 2
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