Products

In situ Proximity Ligation Assay (Cell)

Entrez GeneID

Gene Name

SKP1

Gene Alias

EMC19, MGC34403, OCP-II, OCP2, SKP1A, TCEB1L, p19A

Gene Description

S-phase kinase-associated protein 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq

Other Designations

RNA polymerase II elongation factor-like protein OCP2|cyclin A/CDK2-associated p19|organ of Corti protein 2|transcription elongation factor B (SIII), polypeptide 1-like

Entrez GeneID

Gene Name

CACYBP

Gene Alias

GIG5, MGC87971, PNAS-107, RP1-102G20.6, S100A6BP, SIP

Gene Description

calcyclin binding protein

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000032884|OTTHUMP00000032885|Siah-interacting protein (SIP)|growth-inhibiting gene 5 protein