Products

In situ Proximity Ligation Assay (Cell)

Entrez GeneID

Gene Name

ACTG1

Gene Alias

ACT, ACTG, DFNA20, DFNA26

Gene Description

actin, gamma 1

Omim ID

Gene Ontology

Gene Summary

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells. [provided by RefSeq

Other Designations

actin, cytoplasmic 2|actin, gamma 1 propeptide|cytoskeletal gamma-actin

Entrez GeneID

Gene Name

VASP

Gene Alias

-

Gene Description

vasodilator-stimulated phosphoprotein

Omim ID

Gene Ontology

Gene Summary

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq

Other Designations

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