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Last updated: 2020/2/23

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ERBB2 monoclonal antibody GMP

  • Catalog # : DH0082
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • ERBB2 rabbit monoclonal antibody.
  • Immunogen:
  • Human recombinant ERBB2
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Concentration:
  • 0.2 mg/mL
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Results

    Sandwich ELISA

    QC Testing of DH0082
    Sandwich ELISA performed with ERBB2 recombinant protein and ERBB2 monoclonal antibody.


    Immunofluorescence

    QC Testing of DH0082
    Immunofluorescence staining performed on SKBR3 cells using ERBB2 monoclonal antibody (0.5ug/mL) with Alexa 488 conjugated anti-rabbit secondary antibody.
  • Recommend Usage:
  • Immunofluorescence (0.5 ug/mL)
    LiquidCell™ SuperSlide™ (0.75 uL per slide)
  • Storage Buffer:
  • PBS (50% glycerol, 0.01% sodium azide, 0.05% BSA)
  • Storage Instruction:
  • Store at -20°C. Do not freeze.
  • Available Test:
  • 16 assays
  • Regulatory Status:
  • GMP grade
  • Instrument Compatibility:
  • Ventana™ BenchMark Stainer
  • Recommend Reagents:
  • Alexa 488 conjugated anti-rabbit secondary antibody (Cat#: A21206, Thermo Fisher)
  • Applications
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining performed on CTCs from the patient recoverd by SuperSlide™. ERBB2 was detected via green signal (Alexa 488).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 2064
  • Gene Name:
  • ERBB2
  • Gene Alias:
  • CD340,HER-2,HER-2/neu,HER2,NEU,NGL,TKR1
  • Gene Description:
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Gene Summary:
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
  • Other Designations:
  • c-erb B2/neu protein,erbB-2,herstatin,neuroblastoma/glioblastoma derived oncogene homolog,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
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