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Last updated: 2017/10/22

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ACTN4/CEN19p FISH Probe (Orange/Green)

  • Catalog # : DF0002
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  • Specification
  • Product Description:
  • Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique.
  • Storage Instruction:
  • Store at 3-5°C in the dark. Please aliquot before use.
  • Note:
  • Hybridization position of the probes on the chromosome.

  • Probe:
        Fluorophore:
        Location:
  • ACTN4/CEN19p
    TAMRA/FITC
    19q13/19p13.11
  • Origin:
  • Human
  • Source:
  • Genomic DNA
  • Regulation Status:
  • For research use only (RUO)
  • Publication Reference
  • Applications
  • DNA Hybridization
  • DNA Hybridization enlargeenlarge this image
  • Human lung cancer (FFPE) stained with ACTN4/CEN19p FISH Probe (Orange/Green).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 81
  • Gene Name:
  • ACTN4
  • Gene Alias:
  • ACTININ-4,DKFZp686K23158,FSGS,FSGS1
  • Gene Description:
  • actinin, alpha 4
  • Gene Summary:
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
  • Other Designations:
  • actinin alpha4 isoform
  • Interactome
  • Interactome
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