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BACE2 polyclonal antibody
- Catalog # : PAB9773
- Visit Frequency :
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- Price
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- 100 ug
- USD $ 335
- order now, ship in 5 days
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BACE2.
- Immunogen:
- A synthetic peptide corresponding to amino acids 44-59 of human BACE2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9712-7.
- 2.
- Expression analysis of BACE2 in brain and peripheral tissues.
Bennett BD, Babu-Khan S, Loeloff R, Louis JC, Curran E, Citron M, Vassar R.J Biol Chem. 2000 Jul 7;275(27):20647-51.
- 3.
- The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
Acquati F, Accarino M, Nucci C, Fumagalli P, Jovine L, Ottolenghi S, Taramelli R.FEBS Lett. 2000 Feb 18;468(1):59-64.
- Entrez GeneID:
- 25825
- Gene Name:
- BACE2
- Gene Alias:
- AEPLC,ALP56,ASP1,ASP21,BAE2,CDA13,CEAP1,DRAP
- Gene Description:
- beta-site APP-cleaving enzyme 2
- Omim ID:
- 605668
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- 56 kDa aspartic-like protease,Down syndrome region aspartic protease,aspartyl protease 1,beta secretase 2,beta-site amyloid beta A4 precursor protein-cleaving enzyme 2,memapsin-1,membrane-associated aspartic protease 1,transmembrane aspartic proteinase As
- Gene Pathway
