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ALOX5 (phospho S523) polyclonal antibody   

  • Catalog # : PAB9606
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  • 100 uL
  • USD $ 415
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of ALOX5.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S523 of human ALOX5.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 80
  • Reactivity:
  • Human, Primates, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot of rat cortex lysate showing specific immunolabeling of the ~80k doublet of ALOX5 phosphorylated at Ser523 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-Ptase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the ALOX5 (phospho S523) polyclonal antibody (Cat # PAB9606). The immunolabeling is completely eliminated by treatment with lambda-Ptase.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 240
  • Gene Name:
  • ALOX5
  • Gene Alias:
  • 5-LO,5-LOX,5LPG,LOG5,MGC163204
  • Gene Description:
  • arachidonate 5-lipoxygenase
  • Gene Summary:
  • This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000019502,arachidonic acid 5-lipoxygenase,leukotriene A4 synthase
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