TLR4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
Immunogen
A synthetic peptide corresponding to amino acids 970-1000 of human TLR4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:20000)
Dot Blot (1:20000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
Dot Blot
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Gene Info — TLR4
Entrez GeneID
7099Gene Name
TLR4
Gene Alias
ARMD10, CD284, TOLL, hToll
Gene Description
toll-like receptor 4
Omim ID
603030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
Other Designations
OTTHUMP00000022807|homolog of Drosophila toll
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Interactome
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Pathway
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Disease
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Publication Reference
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TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.
The Journal of Biological Chemistry 2003 Dec; 278(50):49751.
Application:WB-Tr, Human, HEK 293 cells.
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.
The Journal of Experimental Medicine 2003 Sep; 198(7):1043.
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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.
Nature Immunology 2003 Feb; 4(2):161.
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TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
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