CXCR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CXCR1.
Immunogen
A synthetic peptide corresponding to amino acids 13-30 of human CXCR1.
Sequence
DDLNFTGNPPADEDYSPC
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500)
Immunoprecipitation (1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot of CXCR1 polyclonal antibody (Cat # PAB8941) with protein-coupled CXCR1. Antibody dilution at 1:500.Immunohistochemistry
Immunoprecipitation
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Gene Info — CXCR1
Entrez GeneID
3577Gene Name
CXCR1
Gene Alias
C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Gene Description
chemokine (C-X-C motif) receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
Other Designations
receptor|alpha|interleukin-8 receptor type 1|interleukin-8 receptor type A
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Interactome
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Pathway
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Disease
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Publication Reference
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Chemokine receptors: signposts to brain development and disease.
Tran PB, Miller RJ.
Nature Reviews. Neuroscience 2003 Jun; 4(6):444.
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Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1.
Ramjeesingh R, Leung R, Siu CH.
FASEB Journal 2003 Jul; 17(10):1292.
Application:Func, WB, Human, WM239, WM35 cells.
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The role of chemokines and chemokine receptors in progressive renal diseases.
Segerer S.
American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 2003 Mar; 41(3 Suppl 1):S15.
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Chemokine receptors: signposts to brain development and disease.
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