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Last updated: 2014/8/25
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CTSB polyclonal antibody

  • Catalog # : PAB8632
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CTSB.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding amino acids 322 of human CTSB.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 37-43, 25
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • The purified antibody detects both the proform (37-43 KDa) and the mature form (25 KDa) of cathepsin B. It reacts with human and mouse and in a lesser extent with rat samples.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    Immunohistochemistry (10-20 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of CTSB expression in Jurkat cell (Lane 1) and mouse small intestine tissue (Lane 2) lysate.
  • Immunohistochemistry
  • Application Image
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 1508
  • Gene Name:
  • CTSB
  • Gene Alias:
  • APPS,CPSB
  • Gene Description:
  • cathepsin B
  • Gene Summary:
  • The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
  • Other Designations:
  • APP secretase,OTTHUMP00000116009,amyloid precursor protein secretase,cathepsin B1,cysteine protease,preprocathepsin B
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