AURKA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against a recombinant AURKA.
Immunogen
Recombinant GST fusion protein corresponding to human AURKA.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (0.5-2 ug/mL)
Immunohistochemistry (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using AURKA polyclonal antibody (Cat # PAB8466) . -
Gene Info — AURKA
Entrez GeneID
6790Gene Name
AURKA
Gene Alias
AIK, ARK1, AURA, AURORA2, BTAK, MGC34538, STK15, STK6, STK7
Gene Description
aurora kinase A
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
IPL1-related kinase|OTTHUMP00000031340|OTTHUMP00000031342|OTTHUMP00000031343|OTTHUMP00000031344|OTTHUMP00000031345|OTTHUMP00000166071|aurora-A|aurora-related kinase 1|aurora/IPL1-like kinase|breast-tumor-amplified kinase|serine/threonine kinase 15|serine/
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Interactome
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Disease
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Publication Reference
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Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1.
Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y.
The Journal of Biological Chemistry 2002 Mar; 277(12):10719.
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Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.
Giet R, Prigent C.
Journal of Cell Science 1999 Nov; 112 ( Pt 21):3591.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
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Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets.
Broekman MJ, Handin RI, Cohen P.
British Journal of Haematology 1975 Sep; 31(1):51.
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Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1.
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