Immunohistochemistry using MAPT polyclonal antibody (Cat # PAB8046) showing excellent staining of MAPT aggregations within human neural tissue and within neuronal axons MAPT threads (arrows) in. It is light IHC using MAPT polyclonal antibody (Cat # PAB8046) (1/8000) with Jackson biotinylated donkey anti rabbit secondary antibody (1/2000) followed by Sigma Extra avidin peroxidase (1/400) and DAB substrate and a very light hematoxylin counter stain.
Immunofluorescence
Immunohistochemistry using MAPT polyclonal antibody (Cat # PAB8046) showing excellent staining of MAPT aggregations within human neural tissue. It is a confocal IHC image of MAPT polyclonal antibody (Cat # PAB8046) at 1/400 dilution with Jackson Cy2 secondary antibody (1/100) .
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq
Other Designations:
G protein beta1/gamma2 subunit-interacting factor 1,microtubule-associated protein tau, isoform 4