ABCB5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCB5.
Immunogen
A synthetic peptide corresponding to internal region of human ABCB5.
Sequence
C-QTQHRNTSKKAQ
Host
Goat
Theoretical MW (kDa)
89.8
Reactivity
Human
Specificity
This antibody is expected to recognise both reported isoforms (NP_848654.3; NP_001157413.1)
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ABCB5 polyclonal antibody (Cat # PAB7511) (0.3 ug/mL) staining of human skin lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — ABCB5
Entrez GeneID
340273Protein Accession#
NP_848654.3;NP_001157413.1Gene Name
ABCB5
Gene Alias
ABCB5alpha, ABCB5beta, EST422562
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 5
Gene Ontology
HyperlinkGene Summary
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM
Other Designations
ATP-binding cassette protein|ATP-binding cassette, sub-family B, member 5|P-glycoprotein ABCB5
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Pathway
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Disease
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Publication Reference
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ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH.
Cancer Research 2005 May; 65(10):4320.
Application:Func, IF, IHC, Flow Cyt, Human, Human malignant melanoma sections, G3361 cells.
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ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
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