CYP19A1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CYP19A1.
Immunogen
A synthetic peptide corresponding to human CYP19A1.
Sequence
C-HDLSLHPDETKN
Host
Goat
Theoretical MW (kDa)
57.9
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000094.2 and NP_112503.1), which are identical.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CYP19A1 polyclonal antibody (Cat # PAB7447) (0.1 ug/mL) staining of human placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP19A1
Entrez GeneID
1588Protein Accession#
NP_000094.2;NP_112503.1Gene Name
CYP19A1
Gene Alias
ARO, ARO1, CPV1, CYAR, CYP19, MGC104309, P-450AROM
Gene Description
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000162543|aromatase|cytochrome P450, family 19|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Aromatase inhibitors for the treatment of breast cancer: is tamoxifen of historical interest only?
Van Poznak CH, Hayes DF.
Journal of the National Cancer Institute 2006 Sep; 98(18):1261.
Application:WB-Ce, Human, Human breast cancer cells.
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Aromatase inhibitors for the treatment of breast cancer: is tamoxifen of historical interest only?
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