ARSB polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ARSB.
Immunogen
A synthetic peptide corresponding to human ARSB.
Sequence
C-KLARGHTNGTKPLD
Host
Goat
Theoretical MW (kDa)
59.7, 46
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000037.2, NP_942002.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western blot (0.03-0.1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ARSB polyclonal antibody (Cat # PAB7369) (0.03 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ARSB polyclonal antibody (Cat # PAB7369, 5 ug/mL) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARSB
Entrez GeneID
411Protein Accession#
NP_000037.2;NP_942002.1Gene Name
ARSB
Gene Alias
ASB, G4S, MPS6
Gene Description
arylsulfatase B
Gene Ontology
HyperlinkGene Summary
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
N-acetylgalactosamine-4-sulfatase|OTTHUMP00000135268
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Interactome
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Pathway
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Disease
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Publication Reference
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Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.
Bhattacharyya S, Look D, Tobacman JK.
Clinica Chimica Acta; International Journal of Clinical Chemistry 2007 May; 380(1-2):122.
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Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.
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