F13A1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of F13A1.
Immunogen
A synthetic peptide corresponding to amino acids 703-717 of human F13A1.
Sequence
C-HRKLIASMSSDSLRH
Host
Goat
Theoretical MW (kDa)
83.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.05-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
F13A1 polyclonal antibody (Cat # PAB7368) (0.1 ug/mL) staining of human placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — F13A1
Entrez GeneID
2162Protein Accession#
NP_000120.2Gene Name
F13A1
Gene Alias
F13A
Gene Description
coagulation factor XIII, A1 polypeptide
Omim ID
134570Gene Ontology
HyperlinkGene Summary
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq
Other Designations
FSF, A subunit|TGase|bA525O21.1 (coagulation factor XIII, A1 polypeptide)|coagulation factor XIII A1 subunit|coagulation factor XIII, A polypeptide|factor XIIIa|fibrin stabilizing factor, A subunit|fibrinoligase|protein-glutamine gamma-glutamyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
Higaki S, Nakano K, Onaka S, Amano A, Tanioka Y, Harada K, Hashimoto S, Sakaida I, Okita K.
Journal of Gastroenterology and Hepatology 2006 Sep; 21(9):1407.
Application:Flow Cyt, Human, White blood cells from patients with Crohn's disease.
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Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
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