APH1A polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
APH1A polyclonal antibody (Cat # PAB7304) (0.05 ug/mL) staining of human brain (cerebral cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
-
Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of APH1A.
Immunogen
A synthetic peptide corresponding to human APH1A.
Sequence
C-HVTDRSDARLQYG
Host
Goat
Theoretical MW (kDa)
28.9, 26.8
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_001071096.1 and NP_057106.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.05-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
APH1A polyclonal antibody (Cat # PAB7304) (0.05 ug/mL) staining of human brain (cerebral cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — APH1A
Entrez GeneID
51107Protein Accession#
NP_001071096.1;NP_057106.2Gene Name
APH1A
Gene Alias
6530402N02Rik, APH-1A, CGI-78
Gene Description
anterior pharynx defective 1 homolog A (C. elegans)
Omim ID
607629Gene Ontology
HyperlinkGene Summary
APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
Other Designations
OTTHUMP00000014528|OTTHUMP00000014529|anterior pharynx defective 1 homolog A
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway.
Spasic D, Raemaekers T, Dillen K, Declerck I, Baert V, Serneels L, Fullekrug J, Annaert W.
The Journal of Cell Biology 2007 Feb; 176(5):629.
Application：WB, Human, HeLa cells.
-
Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com