PODXL polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PODXL.
Immunogen
A synthetic peptide corresponding to C-terminus of human PODXL.
Sequence
C-DNLTKDDLDEEEDTH
Host
Goat
Theoretical MW (kDa)
160, 58.6, 55.4
Reactivity
Human, Mouse, Rat
Specificity
This antibody is expected to recognize both reported isoforms (NP_001018121.1 and NP_005388.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PODXL polyclonal antibody (Cat # PAB7292) (0.5 ug/mL) staining of human kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PODXL
Entrez GeneID
5420Protein Accession#
NP_001018121.1;NP_005388.2Gene Name
PODXL
Gene Alias
Gp200, MGC138240, PC, PCLP
Gene Description
podocalyxin-like
Omim ID
602632Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.
Nielsen JS, Graves ML, Chelliah S, Vogl AW, Roskelley CD, McNagny KM.
PLoS One 2007 Feb; 2(2):e237.
Application:IF, Human, Dog, MCF-7, MDCK cells.
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The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.
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