PSME2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PSME2.
Immunogen
A synthetic peptide corresponding to human PSME2.
Sequence
C-NLEKIVNPKGEEKP
Host
Goat
Theoretical MW (kDa)
27.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PSME2 polyclonal antibody (Cat # PAB7268) (0.5 ug/mL) staining of human spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSME2
Entrez GeneID
5721Protein Accession#
NP_002809.2Gene Name
PSME2
Gene Alias
PA28B, PA28beta, REGbeta
Gene Description
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Omim ID
602161Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq
Other Designations
11S regulator complex beta subunit|MCP activator, 31-kD subunit|activator of multicatalytic protease subunit 2|cell migration-inducing protein 22|proteasome activator 28-beta|proteasome activator hPA28 subunit beta|proteasome activator subunit 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28.
Brychcy M, Kuckelkorn U, Hausdorf G, Egerer K, Kloetzel PM, Burmester GR, Feist E.
Arthritis & Rheumatism 2006 Jul; 54(7):2175.
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Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28.
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