CNTFR polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
CNTFR polyclonal antibody (Cat # PAB7167) (0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CNTFR.
Immunogen
A synthetic peptide corresponding to human CNTFR.
Sequence
CRSNTYPKGFY
Host
Goat
Theoretical MW (kDa)
40.6
Reactivity
Mouse
Specificity
This antibody is expected to recognize both reported isoforms (NP_671693.1, NP_001833.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CNTFR polyclonal antibody (Cat # PAB7167) (0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CNTFR
Entrez GeneID
1271Protein Accession#
NP_671693.1;NP_001833.1Gene Name
CNTFR
Gene Alias
MGC1774
Gene Description
ciliary neurotrophic factor receptor
Omim ID
118946Gene Ontology
HyperlinkGene Summary
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq
Other Designations
CNTFR alpha|OTTHUMP00000021270|OTTHUMP00000021271|ciliary neurotrophic factor receptor alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-alpha) following experimental intracerebral hemorrhage in rats.
Yokota H, Yoshikawa M, Hirabayashi H, Nakase H, Uranishi R, Nishimura F, Sugie Y, Ishizaka S, Sakaki T.
Neuroscience Letters 2005 Apr; 377(3):170.
Application：IF, Rat, Brain.
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Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-alpha) following experimental intracerebral hemorrhage in rats.
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