APBB1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
APBB1 polyclonal antibody (Cat # PAB7086) (0.1 ug/mL) staining of NIH/3T3 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of APBB1.
Immunogen
A synthetic peptide corresponding to human APBB1.
Sequence
C-GSLKPKRLGAHTP
Host
Goat
Theoretical MW (kDa)
77.2, 77
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize both reported isoforms (NP_001155.1 and NP_663722.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
APBB1 polyclonal antibody (Cat # PAB7086) (0.1 ug/mL) staining of NIH/3T3 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — APBB1
Entrez GeneID
322Protein Accession#
NP_001155.1;NP_663722.1Gene Name
APBB1
Gene Alias
FE65, MGC:9072, RIR
Gene Description
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Omim ID
602709Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. [provided by RefSeq
Other Designations
adaptor protein FE65a2|amyloid beta A4 precursor protein-binding, family B, member 1|stat-like protein
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Interactome
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Disease
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Publication Reference
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FE65 interaction with the ApoE receptor ApoEr2.
Hoe HS, Magill LA, Guenette S, Fu Z, Vicini S, Rebeck GW.
The Journal of Biological Chemistry 2006 Aug; 281(34):24521.
Application：IF, IP, WB-Tr, Monkey, Mouse, CIOS-7 cells, Mouse primary cortical neurons.
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FE65 interaction with the ApoE receptor ApoEr2.
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