CYP3A4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CYP3A4.
Immunogen
A synthetic peptide corresponding to human CYP3A4.
Sequence
C-KESRLEDTQKHR
Host
Goat
Theoretical MW (kDa)
57.3
Specificity
This antibody is not expected to cross-react with 3A5, 3A7 ot 3A43.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP3A4
Entrez GeneID
1576Protein Accession#
NP_059488.2Gene Name
CYP3A4
Gene Alias
CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 4
Omim ID
124010Gene Ontology
HyperlinkGene Summary
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq
Other Designations
P450-III, steroid inducible|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450, subfamily IIIA, polypeptide 4|glucocorticoid-inducible P450|nifedipine o
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Publication Reference
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Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.
Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR.
Drug Metabolism and Disposition 2005 Jun; 33(6):714.
Application:Microsomal Assay, Recombinant protein.
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Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.
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