ADRB1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ADRB1 polyclonal antibody (Cat # PAB6975) (6 ug/mL) staining of paraffin embedded Human Heart. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
Immunofluorescence
ADRB1 polyclonal antibody (Cat # PAB6975) Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ADRB1.
Immunogen
A synthetic peptide corresponding to internal region of human ADRB1.
Sequence
ESDEARRCYNDPK
Host
Goat
Theoretical MW (kDa)
51.2
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:2000)
Immunofluorescence (10 ug/mL)
Immunohistochemistry(6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ADRB1 polyclonal antibody (Cat # PAB6975) (6 ug/mL) staining of paraffin embedded Human Heart. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.Immunofluorescence
ADRB1 polyclonal antibody (Cat # PAB6975) Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRB1
Entrez GeneID
153Protein Accession#
NP_000675.1Gene Name
ADRB1
Gene Alias
ADRB1R, B1AR, BETA1AR, RHR
Gene Description
adrenergic, beta-1-, receptor
Gene Ontology
HyperlinkGene Summary
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq
Other Designations
OTTHUMP00000020519|beta-1-adrenergic receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients.
Wallukat G, Munoz Saravia SG, Haberland A, Bartel S, Araujo R, Valda G, Duchen D, Diaz Ramirez I, Borges AC, Schimke I.
Journal of the American College of Cardiology 2010 Feb; 55(5):463.
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Beta1-adrenergic receptors maintain fetal heart rate and survival.
Rashmi Chandra, Andrea L Portbury, Alisa Ray, Margie Ream, Marybeth Groelle, Dona M Chikaraishi.
Biology of the Neonate 2006 Oct; 89(3):147.
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Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients.
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