ADRA2A polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ADRA2A.
Immunogen
A synthetic peptide corresponding to human ADRA2A.
Sequence
C-TERRPNGLGPERS
Host
Goat
Theoretical MW (kDa)
49
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRA2A
Entrez GeneID
150Protein Accession#
NP_000672.2Gene Name
ADRA2A
Gene Alias
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Gene Description
adrenergic, alpha-2A-, receptor
Omim ID
104210Gene Ontology
HyperlinkGene Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq
Other Designations
OTTHUMP00000058849|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenoceptor|alpha-2A-adrenergic receptor|alpha-2AAR subtype C10|alpha2A adrenergic receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn.
Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu and Song Cao.
Journal of Neuroinflammation 2022 May; 19(1):123.
Application:IF, Mouse, mosue spinal cord.
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p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.
Tan M, Walwyn WM, Evans CJ, Xie CW.
The Journal of Biological Chemistry 2009 Jan; 284(10):6270.
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Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn.
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