CNR1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CNR1.
Immunogen
A synthetic peptide corresponding to human CNR1.
Sequence
C-HTSEDGKVQVTRPDQ
Host
Goat
Theoretical MW (kDa)
52.9, 45.9
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_057167.2 and NP_149421.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CNR1 polyclonal antibody (Cat # PAB6876) (0.1 ug/mL) staining of rat brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
HEK293 overexpressing CNR1 and probed with CNR1 polyclonal antibody (Cat # PAB6876) (mock transfection in second lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CNR1
Entrez GeneID
1268Protein Accession#
NP_057167.2;NP_149421.1Gene Name
CNR1
Gene Alias
CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
Gene Description
cannabinoid receptor 1 (brain)
Omim ID
114610Gene Ontology
HyperlinkGene Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000016838|OTTHUMP00000016839|OTTHUMP00000016840|central cannabinoid receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Dysfunction in Fatty Acid amide hydrolase is associated with depressive-like behavior in wistar kyoto rats.
Vinod KY, Xie S, Psychoyos D, Hungund BL, Cooper TB, Tejani-Butt SM.
PLoS One 2012 May; 7(5):e36743.
Application:WB-Ti, Rat, Rat brain.
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Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F, Bohme GA, Imperato A, Pedrazzini T, Roques BP, Vassart G, Fratta W, Parmentier M.
Science 1999 Jan; 283(5400):401.
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Dysfunction in Fatty Acid amide hydrolase is associated with depressive-like behavior in wistar kyoto rats.
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