SERPINE1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
SERPINE1 polyclonal antibody (Cat # PAB6774) (0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SERPINE1 polyclonal antibody (Cat # PAB6774) (4 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Sandwich ELISA
SERPINE1 polyclonal antibody (Cat # PAB6774) (1.5 ug/mL) as the reporter with the capture rabbit antibody (2.5 ug/mL).
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SERPINE1.
Immunogen
A synthetic peptide corresponding to internal region of human SERPINE1.
Sequence
C-GFKIDDKGMAPALRH
Host
Goat
Theoretical MW (kDa)
45.1
Reactivity
Human
Specificity
This antibody is expected to recognise both reported isoforms.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Sandwhich ELISA (1.5-3 ug/mL)
Western Blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SERPINE1 polyclonal antibody (Cat # PAB6774) (0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SERPINE1 polyclonal antibody (Cat # PAB6774) (4 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
Sandwich ELISA
SERPINE1 polyclonal antibody (Cat # PAB6774) (1.5 ug/mL) as the reporter with the capture rabbit antibody (2.5 ug/mL). -
Gene Info — SERPINE1
Entrez GeneID
5054Protein Accession#
NP_000593.1;NP_001158885.1Gene Name
SERPINE1
Gene Alias
PAI, PAI-1, PAI1, PLANH1
Gene Description
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Omim ID
173360Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
plasminogen activator inhibitor, type I|plasminogen activator inhibitor-1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of mast cells by incorporation of cholesterol into rafts.
Baumruker T, Csonga R, Pursch E, Pfeffer A, Urtz N, Sutton S, Bofill-Cardona E, Cooke M, Prieschl E.
International Immunology 2003 Oct; 15(10):1207.
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Activation of mast cells by incorporation of cholesterol into rafts.
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