NR1H2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
NR1H2 polyclonal antibody (Cat # PAB6690) (1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NR1H2 polyclonal antibody (Cat # PAB6690) (3 ug/mL) staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NR1H2.
Immunogen
A synthetic peptide corresponding to human NR1H2.
Sequence
SSPTTSSLDTPLPGC
Host
Goat
Theoretical MW (kDa)
51
Reactivity
Human
Specificity
This antibody is expected to be specific to LXR beta and not to cross-react with LXR alpha.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western blot (1-3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NR1H2 polyclonal antibody (Cat # PAB6690) (1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NR1H2 polyclonal antibody (Cat # PAB6690) (3 ug/mL) staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NR1H2
Entrez GeneID
7376Protein Accession#
NP_009052Gene Name
NR1H2
Gene Alias
LXR-b, LXRB, NER, NER-I, RIP15, UNR
Gene Description
nuclear receptor subfamily 1, group H, member 2
Omim ID
600380Gene Ontology
HyperlinkGene Summary
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM
Other Designations
LX receptor beta|liver X receptor beta|liver X receptor-beta|nuclear orphan receptor LXR-beta|oxysterols receptor LXR-beta|steroid hormone-nuclear receptor NER|ubiquitously-expressed nuclear receptor
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Interactome
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Disease
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Publication Reference
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.
PNAS 2002 Sep; 99(18):11896.
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
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