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Last updated: 2014/8/25
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ACTL6A/ACTL6B polyclonal antibody

  • Catalog # : PAB6615
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of ACTL6A/ACTL6B.
  • Immunogen:
  • A synthetic peptide corresponding to human ACTL6A/ACTL6B.
  • Sequence:
  • YEEGGKQCVERKCP
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 47.5, 43.2, 46.9
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize both BAF53A and BAF53B, which are almost identical.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:64000)
    Western Blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • The ACTL6A/ACTL6B polyclonal antibody (Cat # PAB6615) staining (1 ug/mL) of HeLa lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Protein Accession#:
  • NP_057272 (Gene ID : 51412);NP_004292 (Gene ID : 86)
  • Gene Name:
  • ACTL6B
  • Gene Alias:
  • ACTL6,BAF53B
  • Gene Description:
  • actin-like 6B
  • Gene Summary:
  • The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. [provided by RefSeq
  • Other Designations:
  • 53 kDa BRG1-associated factor B,actin-like 6,actin-related protein,hArpN alpha
  • Gene Information
  • Entrez GeneID:
  • 86
  • Protein Accession#:
  • NP_057272 (Gene ID : 51412);NP_004292 (Gene ID : 86)
  • Gene Name:
  • ACTL6A
  • Gene Alias:
  • ACTL6,ARPN-BETA,Arp4,BAF53A,INO80K,MGC5382
  • Gene Description:
  • actin-like 6A
  • Gene Summary:
  • This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq
  • Other Designations:
  • BAF complex 53 kDa subunit,BAF53,BRG1-associated factor,INO80 complex subunit K,actin-related protein 4,hArpN beta
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