BLNK polyclonal antibody
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More Files
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Western Blot (Cell lysate)
BLNK polyclonal antibody (Cat # PAB6035) staining (4 ug/mL) of Daudi lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BLNK.
Immunogen
A synthetic peptide corresponding to human BLNK.
Sequence
C-KDSTRLKYAVKVS
Host
Goat
Theoretical MW (kDa)
50.5, 48.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
BLNK polyclonal antibody (Cat # PAB6035) staining (4 ug/mL) of Daudi lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BLNK
Entrez GeneID
29760Protein Accession#
NP_037446.1Gene Name
BLNK
Gene Alias
BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65
Gene Description
B-cell linker
Omim ID
604515Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
B cell linker protein|B-cell adapter containing a SH2 domain protein|B-cell adapter containing a Src homology 2 domain protein|OTTHUMP00000020167|Src homology 2 domain-containing leukocyte protein of 65 kDa
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Interactome
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Pathway
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Disease
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Publication Reference
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BLNK: a central linker protein in B cell activation.
Fu C, Turck CW, Kurosaki T, Chan AC.
Immunity 1998 Jul; 9(1):93.
Application：WB-Ce, WB-Tr, Human, Mouse, Rat, 70Z/3, A20, Daudi, EL4, HEK 293, Jurkat, K-562, LAK, Raji, Ramos, RBL-1, THP-1, WEHI-231 cells.
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BLNK: a central linker protein in B cell activation.
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