HDAC8 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells using HDAC8 polyclonal antibody (Cat # PAB5387) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HDAC8 polyclonal antibody (Cat # PAB5387) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC8.
Immunogen
A synthetic peptide corresponding to residues surrounding S39 of human HDAC8.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells using HDAC8 polyclonal antibody (Cat # PAB5387) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HDAC8 polyclonal antibody (Cat # PAB5387) . -
Gene Info — HDAC8
Entrez GeneID
55869Gene Name
HDAC8
Gene Alias
HDACL1, RPD3
Gene Description
histone deacetylase 8
Omim ID
300269Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. [provided by RefSeq
Other Designations
histone deacetylase-like 1
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Interactome
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Disease
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Publication Reference
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Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
Lee H, Rezai-Zadeh N, Seto E.
Molecular and Cellular Biology 2004 Jan; 24(2):765.
Application：IP-WB, Human, HeLa cells.
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Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
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