BIRC3 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of A-549 cell lysate (35 ug/lane) with BIRC3 polyclonal antibody (Cat # PAB4708).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BIRC3 polyclonal antibody (Cat # PAB4708) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BIRC3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of A-549 cell lysate (35 ug/lane) with BIRC3 polyclonal antibody (Cat # PAB4708).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BIRC3 polyclonal antibody (Cat # PAB4708) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — BIRC3
Entrez GeneID
330Protein Accession#
BIR3_HUMANGene Name
BIRC3
Gene Alias
AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49
Gene Description
baculoviral IAP repeat-containing 3
Omim ID
601721Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq
Other Designations
TNFR2-TRAF signaling complex protein|apoptosis inhibitor 2|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma.
Suguro-Katayama M, Suzuki R, Kasugai Y, Nakamura T, Suzuki H, Hosokawa Y, Shiku H, Nakamura S, Seto M.
Leukemia 2003 Dec; 17(12):2508.
-
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.
Wang Q, Wang X, Evers BM.
The Journal of Biological Chemistry 2003 Dec; 278(51):51091.
Application：WB, Human, Caco-2 cells.
-
cIAP-2 block apoptotic events in bladder cancer cells.
Jonsson G, Paulie S, Grandien A.
Anticancer Res 2003 Jul; 23(4).
-
Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com