PINK1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PINK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PINK1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PINK1 polyclonal antibody (Cat # PAB4484) in mouse kidney tissue lysate . PINK1 (arrow) was detected using the purified PINK1 polyclonal antibody (Cat # PAB4484) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PINK1 polyclonal antibody (Cat # PAB4484) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PINK1
Entrez GeneID
65018Protein Accession#
NP_115785.1Gene Name
PINK1
Gene Alias
BRPK, FLJ27236, PARK6
Gene Description
PTEN induced putative kinase 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq
Other Designations
OTTHUMP00000002881|protein kinase BRPK|serine/threonine-protein kinase PINK1
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Interactome
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Disease
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Publication Reference
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PINK1 depletion sensitizes non-small cell lung cancer to glycolytic inhibitor 3-bromopyruvate: Involvement of ROS and mitophagy.
Dai K, Radin DP, Leonardi D.
Pharmacological Reports : PR 2019 Aug; 71(6):1184.
Application:ELISA, Human, A-549 cells.
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ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to hepatosteatosis.
Wang L, Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji Q, Shi Y.
Hepatology 2015 Feb; 61(2):486.
Application:WB-Ti, Mouse, Liver.
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PINK1 depletion sensitizes non-small cell lung cancer to glycolytic inhibitor 3-bromopyruvate: Involvement of ROS and mitophagy.
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