REL polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of REL polyclonal antibody (Cat # PAB4433) in mouse kidney tissue lysate . REL (arrow) was detected using the purified REL polyclonal antibody (Cat # PAB4433) .
Western Blot (Cell lysate)
Western blot analysis of REL polyclonal antibody (Cat # PAB4433) in Jurkat cell line lysate . REL (arrow) was detected using the purified REL polyclonal antibody (Cat # PAB4433) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of REL.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human REL.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of REL polyclonal antibody (Cat # PAB4433) in mouse kidney tissue lysate . REL (arrow) was detected using the purified REL polyclonal antibody (Cat # PAB4433) .Western Blot (Cell lysate)
Western blot analysis of REL polyclonal antibody (Cat # PAB4433) in Jurkat cell line lysate . REL (arrow) was detected using the purified REL polyclonal antibody (Cat # PAB4433) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — REL
Entrez GeneID
5966Protein Accession#
NP_002899;Q04864Gene Name
REL
Gene Alias
C-Rel
Gene Description
v-rel reticuloendotheliosis viral oncogene homolog (avian)
Omim ID
164910Gene Ontology
HyperlinkGene Summary
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM
Other Designations
C-Rel proto-oncogene protein|oncogene REL, avian reticuloendotheliosis|v-rel avian reticuloendotheliosis viral oncogene homolog|v-rel reticuloendotheliosis viral oncogene homolog
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Interactome
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Disease
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Publication Reference
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Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.
Jain A, Ma CA, Lopez-Granados E, Means G, Brady W, Orange JS, Liu S, Holland S, Derry JM.
The Journal of Clinical Investigation 2004 Dec; 114(11):1593.
Application：GSA, WB-Ce, Human, CD19+ B cells.
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Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma.
Xiao Q, Shen N, Hedvat CV, Moskowitz CH, Sussman LK, Filippa DA, Zelenetz AD, Houldsworth J, Chaganti RS, Teruya-Feldstein J.
Applied Immunohistochemistry & Molecular Morphology 2004 Sep; 12(3):211.
Application：IHC-P, WB, Human, Human Hodgkin lymphoma.
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Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas.
Houldsworth J, Olshen AB, Cattoretti G, Donnelly GB, Teruya-Feldstein J, Qin J, Palanisamy N, Shen Y, Dyomina K, Petlakh M, Pan Q, Zelenetz AD, Dalla-Favera R, Chaganti RS.
Blood 2004 Mar; 103(5):1862.
Application：IF, IHC-P, WB, Human, Human diffuse large B-cell lymphomas.
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Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.
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