CLCN4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of chicken brain tissue incubated with CLCN4 polyclonal antibody (Cat # PAB4423) . Data courtesy of Emily McMains, Louisiana State University .
Immunofluorescence
Immunofluorescence image of cultured chick retinal amacrine (neuronal) cells labeled with CLCN4 polyclonal antibody (Cat # PAB4423). Data courtesy of Emily McMains, Louisiana State University .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CLCN4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CLCN4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of chicken brain tissue incubated with CLCN4 polyclonal antibody (Cat # PAB4423) . Data courtesy of Emily McMains, Louisiana State University .Immunofluorescence
Immunofluorescence image of cultured chick retinal amacrine (neuronal) cells labeled with CLCN4 polyclonal antibody (Cat # PAB4423). Data courtesy of Emily McMains, Louisiana State University .Enzyme-linked Immunoabsorbent Assay
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Gene Info — CLCN4
Entrez GeneID
1183Protein Accession#
NP_001821;P51793Gene Name
CLCN4
Gene Alias
CLC4, ClC-4, ClC-4A, MGC163150
Gene Description
chloride channel 4
Omim ID
302910Gene Ontology
HyperlinkGene Summary
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. [provided by RefSeq
Other Designations
OTTHUMP00000022893
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Interactome
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Publication Reference
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Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin.
Wang T, Weinman SA.
Gastroenterology 2004 Apr; 126(4):1157.
Application：WB, Mouse, CHO-K1 cells, Mouse tissues.
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Expression of CLCN voltage-gated chloride channel genes in human blood vessels.
Lamb FS, Clayton GH, Liu BX, Smith RL, Barna TJ, Schutte BC.
Journal of Molecular and Cellular Cardiology 1999 Mar; 31(3):657.
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A new region of conservation is defined between human and mouse X chromosomes.
Dinulos MB, Bassi MT, Rugarli EI, Chapman V, Ballabio A, Disteche CM.
Genomics 1996 Jul; 35(1):244.
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Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin.
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