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Last updated: 2014/10/27
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RCAN1 polyclonal antibody

  • Catalog # : PAB4385
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of RCAN1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to internal region of human RCAN1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • ELISA (1:1000)
    Western Blot (1:100-500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Endothelial cell lysate transferred to membrane was incubated with RCAN1 polyclonal antibody (Cat # PAB4385) at a 1 : 500 dilution in 2% BSA in TBST at 4°C overnight . Data courtesy of Dr . Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor .
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1827
  • Protein Accession#:
  • NP_004405;Q7Z555
  • Gene Name:
  • RCAN1
  • Gene Alias:
  • ADAPT78,CSP1,DSC1,DSCR1,MCIP1,RCN1
  • Gene Description:
  • regulator of calcineurin 1
  • Gene Summary:
  • The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • Down syndrome candidate region 1,Down syndrome critical region gene 1,calcipressin 1,calcium and oxidant-inducible mRNA,modulatory calcineurin-interacting protein 1,myocyte-enriched calcineurin-interacting protein 1,near DSCR proline-rich protein
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