SPTLC2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
The SPTLC2 polyclonal antibody (Cat # PAB4377) is used in Western blot to detect SPTLC2 in mouse liver tissue lysate .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPTLC2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 532-562 of human SPTLC2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The SPTLC2 polyclonal antibody (Cat # PAB4377) is used in Western blot to detect SPTLC2 in mouse liver tissue lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPTLC2
Entrez GeneID
9517Protein Accession#
LCB2_HUMANGene Name
SPTLC2
Gene Alias
KIAA0526, LCB2, SPT2
Gene Description
serine palmitoyltransferase, long chain base subunit 2
Omim ID
605713Gene Ontology
HyperlinkGene Summary
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
serine palmitoyltransferase, subunit II
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Interactome
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Pathway
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Publication Reference
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Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis.
Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H.
The Journal of Investigative Dermatology 2002 Nov; 119(5):1048.
Application：IHC-Fr, Human, Human epidermis.
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Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W Jr, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ.
PNAS 2000 Mar; 97(7):3491.
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Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis.
Weiss B, Stoffel W.
European Journal of Biochemistry 1997 Oct; 249(1):239.
Application：WB-Ce, WB-Tr, Human, HEK 293 cells.
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Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis.
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