FNTA polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
The FNTA polyclonal antibody (Cat # PAB4326) is used in Western blot to detect FNTA in mouse brain tissue lysate .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FNTA.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human FNTA.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The FNTA polyclonal antibody (Cat # PAB4326) is used in Western blot to detect FNTA in mouse brain tissue lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — FNTA
Entrez GeneID
2339Protein Accession#
NP_002018;P49354Gene Name
FNTA
Gene Alias
FPTA, MGC99680, PGGT1A, PTAR2
Gene Description
farnesyltransferase, CAAX box, alpha
Omim ID
134635Gene Ontology
HyperlinkGene Summary
Prenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
FTase-alpha|GGTase-I-alpha|farnesyltransferase alpha-subunit|protein prenyltransferase alpha subunit repeat containing 2|ras proteins prenyltransferase alpha|type I protein geranyl-geranyltransferase alpha subunit
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Interactome
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Disease
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Publication Reference
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Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
Annika Klimpel, Katharina Stillger, Janica L Wiederstein, Marcus Krüger, Ines Neundorf.
The FEBS Journal 2021 May; 288(9):2911.
Application：WB-Ce, Human, Mouse, Capan-1, HeLa, LS174T, MCF-7, MEFs, PANC-1 cells .
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The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
Wang T, Danielson PD, Li BY, Shah PC, Kim SD, Donahoe PK.
Science 1996 Feb; 271(5252):1120.
Application：IP, Monkey, COS cells.
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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.
Zhang FL, Diehl RE, Kohl NE, Gibbs JB, Giros B, Casey PJ, Omer CA.
The Journal of Biological Chemistry 1994 Feb; 269(5):3175.
Application：WB-Re, Recombinant proteins.
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cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.
Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U.
Genomics 1993 Oct; 18(1):105.
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Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
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