LLGL2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LLGL2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LLGL2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LLGL2 polyclonal antibody (Cat # PAB4249) in 293 cell line lysate (35 ug/lane). LLGL2 (arrow) was detected using the purified LLGL2 polyclonal antibody (Cat # PAB4249) (1 : 20 dilution).Enzyme-linked Immunoabsorbent Assay
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Gene Info — LLGL2
Entrez GeneID
3993Protein Accession#
NP_004515;Q6P1M3Gene Name
LLGL2
Gene Alias
HGL, LGL2
Gene Description
lethal giant larvae homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
human giant larvae homolog|lethal giant larvae homolog 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.
Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y.
The Journal of Biological Chemistry 2005 Feb; 280(8):6761.
Application:IF, IP-WB, WB-Ce, WB-Tr, Human, HEK293 cells.
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Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico.
Katoh M, Katoh M.
International Journal of Oncology 2004 Mar; 24(3):737.
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Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.
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