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- Home > Products > Polyclonal Ab > Human > Others > UBQLN1 polyclonal antibody
UBQLN1 polyclonal antibody
- Catalog # : PAB4236
- Visit Frequency :
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- 100 ug
- USD $ 319
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of UBQLN1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human UBQLN1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins.
Massey LK, Mah AL, Ford DL, Miller J, Liang J, Doong H, Monteiro MJ.J Alzheimers Dis. 2004 Feb;6(1):79-92.
- 2.
- Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase.
Gao L, Tu H, Shi ST, Lee KJ, Asanaka M, Hwang SB, Lai MM.J Virol. 2003 Apr;77(7):4149-59.
- 3.
- Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.
Mah AL, Perry G, Smith MA, Monteiro MJ.J Cell Biol. 2000 Nov 13;151(4):847-62.
- Applications
- Western Blot (Tissue lysate)
- The UBQLN1 polyclonal antibody (Cat # PAB4236) is used in Western blot to detect UBQLN1 in mouse cerebellum tissue lysate .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with UBQLN1 polyclonal antibody (Cat # PAB4236) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
- Entrez GeneID:
- 29979
- Protein Accession#:
- NP_444295;Q8IXS9
- Gene Name:
- UBQLN1
- Gene Alias:
- DA41,DSK2,FLJ90054,PLIC-1,XDRP1
- Gene Description:
- ubiquilin 1
- Omim ID:
- 605046
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021544,OTTHUMP00000021545
