USP25 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
The USP25 polyclonal antibody (Cat # PAB4213) is used in Western blot to detect USP25 in USP25-transfected HeLa cell lysates . Transfection data is kindly provided by Dr . B . Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of USP25.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human USP25.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
The USP25 polyclonal antibody (Cat # PAB4213) is used in Western blot to detect USP25 in USP25-transfected HeLa cell lysates . Transfection data is kindly provided by Dr . B . Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — USP25
Entrez GeneID
29761Protein Accession#
UB25_HUMANGene Name
USP25
Gene Alias
USP21
Gene Description
ubiquitin specific peptidase 25
Omim ID
604736Gene Ontology
HyperlinkGene Summary
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM
Other Designations
deubiquitinating enzyme 25|ubiquitin carboxyl-terminal hydrolase 25|ubiquitin specific protease 25|ubiquitin thiolesterase 25|ubiquitin-specific processing protease 25
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Interactome
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Disease
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Publication Reference
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K
Nature Genetics 2003 Dec; 36(1):40.
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Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment.
Groet J, Ives JH, Jones TA, Danton M, Flomen RH, Sheer D, Hrascan R, Pavelic K, Nizetic D.
Genes, Chromosomes & Cancer 2000 Feb; 27(2):153.
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USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2.
Valero R, Marfany G, Gonzalez-Angulo O, Gonzalez-Gonzalez G, Puelles L, Gonzalez-Duarte R.
Genomics 1999 Dec; 62(3):395.
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
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