PPP6C polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
The PPP6C polyclonal antibody (Cat # PAB4173) is used in Western blot to detect PPP6C in Thymus tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with PPP6C polyclonal antibody (Cat # PAB4173) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP6C.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to 1-30 amino acids at N-terminus of human PPP6C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PPP6C polyclonal antibody (Cat # PAB4173) is used in Western blot to detect PPP6C in Thymus tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with PPP6C polyclonal antibody (Cat # PAB4173) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPP6C
Entrez GeneID
5537Protein Accession#
NP_006238Gene Name
PPP6C
Gene Alias
FLJ92648, MGC12249
Gene Description
protein phosphatase 6, catalytic subunit
Omim ID
300141Gene Ontology
HyperlinkGene Summary
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq
Other Designations
OTTHUMP00000022122|serine/threonine protein phosphatase catalytic subunit
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Interactome
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Disease
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Publication Reference
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Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
Yang J, Roe SM, Cliff MJ, Williams MA, Ladbury JE, Cohen PT, Barford D.
The EMBO Journal 2004 Dec; 24(1):1.
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Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade.
Zhou G, Golden T, Aragon IV, Honkanen RE.
The Journal of Biological Chemistry 2004 Aug; 279(45):46595.
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Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.
Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ.
The Journal of Biological Chemistry 2004 Jun; 279(35):36490.
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Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
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