PTPN21 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of PTPN21 polyclonal antibody (Cat # PAB4102) in placenta tissue lysate (35 ug/lane). PTPN21 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with PTPN21 polyclonal antibody (Cat # PAB4102) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPN21.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human PTPN21.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PTPN21 polyclonal antibody (Cat # PAB4102) in placenta tissue lysate (35 ug/lane). PTPN21 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with PTPN21 polyclonal antibody (Cat # PAB4102) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN21
Entrez GeneID
11099Protein Accession#
Q16825Gene Name
PTPN21
Gene Alias
PTPD1, PTPRL10
Gene Description
protein tyrosine phosphatase, non-receptor type 21
Omim ID
603271Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq
Other Designations
dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)|protein tyrosine phosphatase D1
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Interactome
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Disease
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Publication Reference
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Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases.
Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM.
The Journal of Biological Chemistry 2000 Dec; 275(52):4124.
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Expression of protein tyrosine phosphatase PTP-RL10 and its isoform in the mouse testis.
Tokuchi H, Higashitsuji H, Nishiyama H, Nonoguchi K, Nagao T, Xue JH, Itoh K, Ogawa O, Fujita J.
International Journal of Urology 1999 Nov; 6(11):572.
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Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases.
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