Western blot analysis of PIK3CG polyclonal antibody (Cat # PAB4069) in HeLa cell lysate (35 ug/lane). PIK3CG (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
Western Blot (Transfected lysate)
Western blot analysis of PIK3CG polyclonal antibody (Cat # PAB4069) in 293 cell lysate transiently transfected with the PIK3CG gene (2 ug/lane). PIK3CG (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
Formalin-fixed and paraffin-embedded human muscle tissue reacted with PIK3CG polyclonal antibody (Cat # PAB4069) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq