GUCY1B3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of GUCY1B3 polyclonal antibody (Cat # PAB4059) in Y-79 cell lysate. GUCY1B3 (arrow) was detected using the purified polyclonal antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GUCY1B3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GUCY1B3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GUCY1B3 polyclonal antibody (Cat # PAB4059) in Y-79 cell lysate. GUCY1B3 (arrow) was detected using the purified polyclonal antibody.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GUCY1B3
Entrez GeneID
2983Protein Accession#
NP_000848Gene Name
GUCY1B3
Gene Alias
GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B1
Gene Description
guanylate cyclase 1, soluble, beta 3
Omim ID
139397Gene Ontology
HyperlinkGene Summary
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Publication Reference
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Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.
Russwurm M, Wittau N, Koesling D.
The Journal of Biological Chemistry 2001 Nov; 276(48):44647.
Application：WB-Ti, Rat, Rat brains, Synaptosomes.
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Guanylyl cyclases and signaling by cyclic GMP.
Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA.
Pharmacological Reviews 2000 Sep; 52(3):375.
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cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.
Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD.
Journal of Cellular Physiology 1996 May; 167(2):213.
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Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.
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