ITPKA polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of ITPKA polyclonal antibody (Cat # PAB4051) in Jurkat cell lysate (35 ug/lane). ITPKA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ITPKA.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ITPKA.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ITPKA polyclonal antibody (Cat # PAB4051) in Jurkat cell lysate (35 ug/lane). ITPKA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ITPKA
Entrez GeneID
3706Protein Accession#
NP_002211Gene Name
ITPKA
Gene Alias
IP3KA
Gene Description
inositol 1,4,5-trisphosphate 3-kinase A
Omim ID
147521Gene Ontology
HyperlinkGene Summary
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region. [provided by RefSeq
Other Designations
1D-myo-inositol-trisphosphate 3-kinase A
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.
Gonzalez B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL.
Molecular Cell 2004 Sep; 15(5):689.
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Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus.
Schell MJ, Erneux C, Irvine RF.
The Journal of Biological Chemistry 2001 Oct; 276(40):37537.
Application：IF, IP, WB-Ti, Rat, Brain.
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Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.
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