ANTXR1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of ANTXR1 polyclonal antibody (Cat # PAB3943) in HeLa cell line lysates (35 ug/lane). ANTXR1 (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinomareacted with ANTXR1 polyclonal antibody (Cat # PAB3943), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ANTXR1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y382 of human ANTXR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ANTXR1 polyclonal antibody (Cat # PAB3943) in HeLa cell line lysates (35 ug/lane). ANTXR1 (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinomareacted with ANTXR1 polyclonal antibody (Cat # PAB3943), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — ANTXR1
Entrez GeneID
84168Protein Accession#
NP_115584;Q9H6X2Gene Name
ANTXR1
Gene Alias
ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Gene Description
anthrax toxin receptor 1
Omim ID
606410Gene Ontology
HyperlinkGene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
2310008J16Rik|2810405N18Rik|tumor endothelial marker 8
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Interactome
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Publication Reference
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Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
Werner E, Kowalczyk AP, Faundez V.
The Journal of Biological Chemistry 2006 Jun; 281(32):23227.
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The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Wei W, Lu Q, Chaudry GJ, Leppla SH, Cohen SN.
Cell 2006 Mar; 124(6):1141.
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Receptor-specific requirements for anthrax toxin delivery into cells.
Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA.
PNAS 2005 Sep; 102(37):13278.
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Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
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